The Number of Man 666 DNA

 The number of man is a number between 1 and 666. This is a total guess but it may be 616

 " a fragment of the papyrus 115 gives the number as 616" google this

Genotype Combinations in Family Pedigrees

Genotype Combinations for Unsampled Individuals:

1. • If some members of the parental generation are not sampled, the number of possible genotype combinations can be much larger.
   • This depends on the number of alleles (k) at each locus. For example, if k=5 among the sampled individuals, we need to account for a potential sixth allele present among the unsampled individuals.
   • Consider a two-locus haplotype (combination of alleles at two different loci). With 5 alleles at each locus, there are 6×6=36 potential two-locus haplotypes.
   • Each unsampled individual can have 36×37/2=666 potential different genotypes.

2. Total Parental Genotype Combinations:

   • In a family where only full siblings are sampled, we consider 666×667/2=222,111 distinct parental genotype combinations.
   • Each of these combinations must be tested against the offspring’s genotypes.

3. Simplifying the Problem:

   • To manage complexity, prior examination of single-locus incompatibilities between parental and offspring genotypes can eliminate many parental genotypes.
   • Algorithms can help identify compatible parental genotypes based on observed offspring genotypes.

4. Polymorphism Levels:

   • The complexity increases exponentially with the number of alleles (approximately the eighth power of k).
   • Researchers often restrict themselves to moderately low levels of polymorphism (k≤5) to handle the computational load.

Remember that this explanation simplifies the topic, but it captures the essential aspects of genotype combinations in family pedigrees. If you have any further questions or need clarification, feel free to ask